Academics

Arya Vaidya Sala Kottakkal - Ministry of AYUSH - Centre of Excellence in Cancer Research


Project Promo Video Link: https://youtu.be/Qt2jZxQJaSs

 

Arya Vaidya Sala Kottakkal (AVS) has been to cancer care by providing Ayurveda treatment for the past 25 years with the intention of improving the quality of life of cancer patients. The efforts have yielded positive results, especially in certain areas like cancers of lung,stomach and prostate etc. Various Ayurveda medicaments including classical formulations and single drugs were found to be effective for managing the symptoms of various cancer conditions. The scientific studies carried out in the Institute on Cancer research have been evidenced by the articles published in various international journals. The Centre of Excellence under AYURSWASTHYA YOJANA has been framed by Ministry of AYUSH with the objectives of delivering the skills to young Ayush professionals based on scientific knowledge in Ayush research. Ministry of AYUSH, Govt. of India has recognized AVS as a Centre of Excellence in Cancer Research in 2022.

 

Project Title & number:       Setting up of Centre of Excellence in Cancer Research (S-12011/6/2021-SCHEME)

 

Objective: Scientific Validation of Selected Ayurvedic Formulations such as GuggulutiktamKashayam, Sahadevi Tablet and Rasasinduram for Stage IV Non-Small Cell Lung Cancer with EGFR-Negative Mutation through Phytochemical, Pharmacological and Clinical Evaluation

 

Names of Principal Investigator and Co-PIs:

Principal Investigator: Dr. P R Ramesh, Chief, Clinical Research, AVS Kottakkal

Co- Principal Investigator:  Dr. Sulaiman C T, Sr. Scientist, Centre for Medicinal Plants Research, Arya Vaidya Sala (AVS), Kottakkal

 

Co-Investigators:

Dr. Mahesh K, Clinical Research, AVS, Kottakkal

Dr. Praveen M, Special OPD, Charitable Hospital, AVS, Kottakkal

Dr. Anandan E M, Chief (Product Development), AVS, Kottakkal

 

Date of commencement of the project       : 01. 04. 2022

 

Area of activity                                              : Phytochemistry/Pharmacology & Clinical Research

 

Total Amount sanctioned

Amount sanctioned -Year wise (lakhs)

Total

1st instalment

2nd instalment

3rd instalment

265.78068

265.78068

132.89034

664.45170

DELIVERABLES Vs ACHIEVEMENTS

Sl. No

Deliverables

Achievements

 

Procurements of Instruments

 

Q-TOF –LC/MS, HPLC, FTNIR, TLC explorer and Freez dryer have been procured and installed successfully

 

Renovation of OP and Lab

 

Special OPD of Charitable hospital and Phytochemistry lab of Centre CMPR have been renovated

 

Procurement of furniture

Furniture for Special OPD and lab furniture for Phytochemistry Division have been procured

 

Quality standardization of raw drugs as per API

 

Quality standardization of all the ingredient drugs has been done as per Ayurvedic Pharmacopoeia of India

 

Preparation of selected formulations

 

Formulations such as GugguluthikthamKashayam (GTK), Sahadevi extract and Rasasinduram have been prepared

 

Preliminary screening and estimations of phytochemicals

Preliminary phytochemical studies have been done for all the ingredient plants and estimation of major class of phytochemicals were also done

 

Quantification of major active compounds

 

Quantification of Caffeic acid and Scopoletin in GTK

Quantification of Betulinic acid and α-amyrin in Sahadevi tablet

 

LC/MS based metabolite profiling of the selected formulation

LC/MS based metabolite profiling of GTK and Sahadevi tablet

 

Acute and sub-acute toxicity studies of the selected formulations

Acute and sub-acute toxicity studies of GTK, Sahadevi and Rasasinduram have been done

 

In-vitro anticancer studies of selected formulations 

Anti-cancer activity of selected three formulations have been done in lung cancer cell line (A549)

 

Evaluation of anti-cancer activity in animal model

Anti-cancer activity of selected formulations in xenograft model

 

Conducting workshop and conferences

1st Workshop has been successfully conducted during 20-22 February, 2023 and Two-day National Conference conducted during 21-22 November, 2025

 

Preparation of SOP &monograph

 

SOP has been prepared for Gugguluthiktham Kashayam, Sahadevi tablet and Rasasinduram

 

Clinical trial of Ca lung patients

Clinical trial is under progress

 

Publication of articles

Four articles have been published in international peer reviewed journals

Publications under the project

  1. Sulaiman C. T., Ramesh P. R, Mahesh K., Anandan E. M, Praveen M. & Indira Balachandran, Scientific validation of the different steps involved in the purification process of Bhallathaka (Semecarpus anacardium L.f.). Essential Chem, 3(1). https://doi.org/10.1080/28378083.2026.2664235
  2. Sulaiman C T, Thasreef Raihana, Shafna T, Ramesh P R, Mahesh K, Praveen M, Anandan E M & Indira Balachandran A validated HPTLC method for quantification of active compounds in a Polyherbal formulation GuggulutiktamKashayam. Vegetos (2025). https://doi.org/10.1007/s42535-025-01195-0
  3. Sulaiman CT, Advaya GR, Shafna T, Ramesh PR, Mahesh K?, Praveen M, Anandan EM, Indira Balachandran, Phytochemistry and bioactives of ingredient plants of a Polyherbal formulation, Next Research,1(2), (2024) https://doi.org/10.1016/j.nexres.2024.100078
  4. Sulaiman C T, Shafna T, Advaya GR, et al. Comparative Chemical Profiling of a Polyherbal Formulation with Respect to its Ingredient Plants Using Spectrophotometric and High-performance Thin-layer Chromatographic Techniques. Pharmacognosy Magazine. 2023; 19(4):917-925. https://doi:10.1177/09731296231200365

  • "The Centre for Medicinal Plants Research functions as a pioneer institute in the area of research, education, conservation and popularisation of Ayurvedic medicinal plants."

  • "The Centre for Medicinal Plants Research functions as a pioneer institute in the area of research, education, conservation and popularisation of Ayurvedic medicinal plants."

  • "The Centre for Medicinal Plants Research functions as a pioneer institute in the area of research, education, conservation and popularisation of Ayurvedic medicinal plants."